SynClub
2025-05-12
Bioinspired Stereoselective Total Synthesis of the Caged Sesquiterpenoid Daphnepapytone A
Y. Zhang, P. Yu, W. Chen, J. Li, K. Liu, X. Xie, H. Li, X. She, Org. Lett. 2025, 27, 5480–5484
2025-28-11
Enantioselective Synthesis of (+)-Auriculatol A
J. K. Thompson, K. C. Youngblood, Y. H. S. Teh, C. M. Farley, Z. Zhang, S. C. Virgil, S. E. Reisman, J. Am. Chem. Soc. 2025, 147, 42170–42174
2025-21-11
Total Synthesis of Bipolamine I
X. Qiu, J. G. Pierce, J. Am. Chem. Soc. 2022, 144, 12638–12641.
2025-14-11
Total Synthesis of Calyciphylline F
R. Sato, R. Sumida, M. Inoue, R. Kotaka, S. Karanjit, K. Namba, Angew. Chem. Int. Ed. 2025, 64, e202517671.
2025-31-10
Asymmetric total synthesis of benzenoid cephalotane-type diterpenoids through a cascade C(sp2) & C(sp3)–H activation
X. Li, Z. Lu, S. Liu, M. Sun, S. Duan, Z. Xie, Nat. Commun. 2025, 16, 4674
2025-17-10
Total Synthesis of Resiniferatoxin
V. H. Vasilev, L. Spessert, K. Yu, T. J. Maimone, J. Am. Chem. Soc. 2022, 144, 16332–16337.
2025-10-10
Total Syntheses of Giraldine I and Heterophyllisine
C. Li, F. Lu, N. Wang, C. Zhang, G. He, W. Lei, J. Liu, J. Wang, X.-Y. Liu, Y. Qin, J. Am. Chem. Soc. 2025, 147, 37012–37018.
2025-03-10
Enantioselective Total Synthesis of Cotylenin A
M. Uwamori, R. Osada, R. Sugiyama, K. Nagatani, M. Nakada, J. Am. Chem. Soc. 2020, 142, 5556–5561.
2025-26-09
A Synthesis of Alsmaphorazine B Demonstrates the Chemical Feasibility of a New Biogenetic Hypothesis
A. Y. Hong, C. D. Vanderwal, J. Am. Chem. Soc. 2015, 137, 7306–7309.
2025-18-09
Total Synthesis of (−)-Psathyrin A Enabled by Radical Cyclization
W. Zhao, R. Al-Ahmad, M. Dai, J. Am. Chem. Soc. 2025, 147, 32365–32369.
2025-11-09
Convergent Total Synthesis of Aleutianamine
J. P. Tuccinardi, J. L. Wood, J. Am. Chem. Soc. 2025, 147, 5736–5742.
2025-04-09
Asymmetric Total Synthesis of (−)-Spirochensilide A
X.-T. Liang, J.-H. Chen, Z. Yang, J. Am. Chem. Soc. 2020, 142, 8116–8121.
2025-28-08
Total Synthesis of (+)-Pierisketone B
Q. Gu, G. D. Walby, M. D. Wood, S. F. Martin, J. Am. Chem. Soc. 2025, 147, 29631–29635.
2025-21-08
A Concise Total Synthesis of Glycinoeclepin A
K. Shen, Q. Wang, T. Zhu, Y. Qiao, P. Hu, J. Am. Chem. Soc. 2025, 147, 23411–23416.
2025-14-08
Total Synthesis of (−)-Neocucurbol C Enabled by Pattern Recognition and MHAT Cyclization
L.-P. Zhong, C. Gudeman, J. Zhen, O. A. Wanasinghe, J. Hellmig, M. J. E. Collins, J. Bacsa, A. Adibekian, M. Dai, J. Am. Chem. Soc. 2025, 147, 28589–28594.
2025-07-08
Enantioselective Total Synthesis of (+)-Aberrarone
W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc. 2022, 144, 15475–15479.
2025-31-07
Enantioselective Total Synthesis of Bipolarolides A and B
Y. Liu, K. Sun, Q. Wei, J. Chen, S. Sun, Y. Li, Z. Feng, Y. Guo, Z. Lu, J. Am. Chem. Soc. 2025, DOI: 10.1021/jacs.5c09835.
2025-24-07
Divergent Asymmetric Synthesis of Bonnadiene and ent-Polytrichastrene B
H. Wang, L. Wei, J. Huang, L. Wang, H. Peng, H. Jiang, J. Wu, Z. Ma, Angew. Chem. Int. Ed. n.d., n/a, e202507961.
2025-17-07
Total Syntheses of Daphenylline, Daphnipaxianine A, and Himalenine D
Y. Chen, W. Zhang, L. Ren, J. Li, A. Li, Angew. Chem. Int. Ed. 2018, 57, 952–956.
2025-10-07
Total Syntheses of Diepoxy-ent-Kaurane Diterpenoids Enabled by a Bridgehead-Enone-Initiated Intramolecular Cycloaddition
Y. Li, Q. Xue, X. Zhao, D. Ma, J. Am. Chem. Soc. 2025, 147, 1197–1206.
2025-03-07
Stereoselective Total Synthesis of Nimbolide
D. B. Ryffel, P. C. Ryffel, M. Martinelli, V. R. Pillai, D. Sarlah, J. Am. Chem. Soc. 2025, 147, 14083–14087.
2025-26-06
Total Synthesis of (−)-Illisimonin A Enabled by Pattern Recognition and Olefin Transposition
B. Xu, Z. Zhang, M. Dai, J. Am. Chem. Soc. 2025, 147, 17592–17597.
2025-19-06
Total Synthesis of Gukulenin B via Sequential Tropolone Functionalizations
K. C. Nicolaou, R. Yu, Z. Lu, F. G. Alvarez, J. Am. Chem. Soc. 2022, 144, 5190–5196.
2025-12-06
Enantioselective Total Synthesis of (–)-Psiguadial A
L. P. O’Grady, M. Achtenhagen, M. F. Wisthoff, R. S. Lewis, K. Pfeifer, W. Zheng, M. I. Martin, G. P. A. Yap, W. J. Chain, Angew. Chem. Int. Ed. e202506537.
2025-04-06
A Concise Synthesis of Pleurotin Enabled by a Nontraditional C–H Epimerization
J. F. Hoskin, E. J. Sorensen, J. Am. Chem. Soc. 2022, 144, 14042–14046.
2025-22-05
Biomimetic Synthesis of Azorellolide via Cyclopropylcarbinyl Cation Chemistry
J. Y. Artzy, D. J. Tantillo, D. H. Trauner, J. Am. Chem. Soc. 2025, 147, 78–83.
2025-15-05
Convergent Total Synthesis of (−)-Calidoustene
W. Yao, Z. Liu, H. Ling, H. Wang, H. Zheng, S.-H. Wang, D.-Y. Zhu, S.-Y. Zhang, X. Chen, J. Am. Chem. Soc. 2025, 147, 15963–15969.
2025-24-04
Total Synthesis of (−)-Cordycicadin D and 3,4-trans-Cordycicadins A and B: Entry to the 3,4-trans-Fused Cordycicadin Framework
L. R. Hunt, P. S. Grant, G. K. Shimokura, D. P. Furkert, M. A. Brimble, Angew. Chem. Int. Ed. 2025, 64, e202419989.
2025-17-04
Total syntheses of schilancidilactones A and B, schilancitrilactone A, and 20-epi-schilancitrilactone A via late-stage nickel-catalyzed cross coupling
H. Wang, X. Zhang, P. Tang, Chem. Sci. 2017, 8, 7246–7250.
2025-10-04
Total Synthesis of Berkeleyone A and Preaustinoid A through Epoxypolyene Cyclization
X. Li, Z. Chang, S. Duan, Z. Xie, Angew. Chem. Int. Ed. 2025, 64, e202416211.
2025-03-04
Asymmetric Total synthesis of Asperones A and B through Organocatalyzed Quinone [5 + 2] Cycloaddition
C. Qu, L. Chen, P. Wang, J. Zhang, Y. Ding, X. Long, T. Zhang, Y. Zhao, J. Deng, J. Am. Chem. Soc. 2025, 147, 6739–6746.
2025-27-03
Total Synthesis of (±)-Leonuketal
P. S. Grant, D. P. Furkert, M. A. Brimble, Org. Lett. 2020, 22, 8735–8740.
2025-20-03
Total Synthesis of DMOA-Derived Meroterpenoids: Achieving Selectivity in the Synthesis of (+)-Berkeleyacetal D and (+)-Peniciacetal I
J. Zhang, X. Luo, J. Zhang, C. Li, J. Am. Chem. Soc. 2025, 147, 5933–5942.
2025-13-03
Concise Total Synthesis of Peyssonnoside A
G. A. Chesnokov, K. Gademann, J. Am. Chem. Soc. 2021, 143, 14083–14088.
2025-06-03
Enantioselective Total Syntheses of Vallesamidine and Schizozygane Alkaloids
G. V. Ramakrishna, Z. Latif and F. Romiti J. Am. Chem. Soc. 2025, 147, 4613-4623.
2025-27-02
Total Synthesis of the Schisandraceae Nortriterpenoid Rubriflordilactone A
G. Chaubet, S. S. Goh, M. Mohammad, B. Gockel, M.-C. A. Cordonnier, H. Baars, A. W. Phillips, E. A. Anderson, Chem. Eur. J. 2017, 23, 14080-14089.
PROBLEM / KEY
2025-20-02
Total Synthesis of Hypersampsone M
A. E. Samkian, S. C. Virgil, B. M. Stoltz, J. Am. Chem. Soc. 2024, 146, 18886–18891.
2025-13-02
Total Synthesis of Lobatamides A and C
S. Yasui, S. Banjo, Y. Nagashima, Y. Okada, K. Yoshikawa, K. Nakata, N. Chida, T. Okamura, T. Sato, Angew. Chem. Int. Ed. 2024, 63, e202402335.
2025-07-02
Concise Synthesis of (−)-Veratramine and (−)-20-iso-Veratramine via Aromative Diels–Alder Reaction
M. D. Zott, D. W. Zuschlag, D. H. Trauner, J. Am. Chem. Soc. 2025, 147, 3010–3016.
2025-30-01
Enantioselective total synthesis of (‒)-lucidumone enabled by tandem prins cyclization/cycloetherification sequence
X.-Z. Liao, R. Wang, X. Wang, G. Li, Nat. Commun. 2024, 15, 2647.
2025-24-01
Ten-Step Total Synthesis of (±)-Phaeocaulisin A Enabled by Cyclopropanol Ring-Opening Carbonylation
Ch. Liu, M. Zhang, L. Zeng, Y. Wan, M. Dai J. Am. Chem. Soc. 2024, 146, 32276-32282.
2025-17-01
Total Synthesis of (±)-Rubriflordilactone A
X. Zheng, X. Guo, H. Wang, P.-P. Zhou, X. Chen, J. Am. Chem. Soc. 2024, 146, 7198–7203.
2025-10-01
Total Synthesis of Isoxeniolide A
L. Betschart, K. H. Altmann Angew. Chem. Int. Ed. 2024, 63, e202315423.
2024-13-12
Total Synthesis of the Norcembranoid Scabrolide B and Its Transformation into Sinuscalide C, Ineleganolide, and Horiolide
D. S. Lin, G. Späth, Z. Meng, L. H. E. Wieske, C. Farès, A. Fürstner, J. Am. Chem. Soc. 2024, 146, 24250–24256.
2024-29-11
Total Synthesis of (+)-Kalmanol
T. Ma, Y. Ma, B. Li, X. Jia, Angew. Chem. Int. Ed. 2024, 63, e202407215.
2024-22-11
Total Synthesis of (+)-Discorhabdin V
B. C. Derstine, A. J. Cook, J. D. Collings, J. Gair, J. Saurí, E. E. Kwan, N. Z. Burns, Angew. Chem. Int. Ed. 2024, 63, e202315284.
2024-15-11
Total Synthesis of Principinol B
Q. Du, Z. Fan, M. Yang, Angew. Chem. Int. Ed. 2024, 63, e202400956.
2024-08-11
Total Synthesis of Putative Melognine
Y. Irie, S. Yokoshima, J. Am. Chem. Soc. 2024, 146, 9526–9531.
2024-01-11
Total Synthesis of (−)-Bipolarolide D
G. A. Chesnokov, J. Friedli, F. J. Carta, K. Gademann, JACS Au, 2024, DOI:10.1021/jacsau.4c00680.
2024-25-10
Asymmetric Total Synthesis of Euphordraculoate A and Pedrolide
C. Tu, Y. Yang, Y. Jiang, Y. Hao, Z. Wang, S. Fu, S. Qin, B. Liu, Angew. Chem. Int. Ed. 2024, 63, e202409997.
2024-18-10
Total Synthesis of the Hexacyclic Sesterterpenoid Niduterpenoid B via Structural Reorganization Strategy
Y. Xue, S. Hou, X. Zhang, F. Zhang, X. Zhang, Y. Tu, J. Am. Chem. Soc. 2024, 146, 25445-25450.
2024-11-10
Total Synthesis of the Guangnanmycin A Alcohol
K. Yahata, A. Fürstner, Angew.Chem. Int. Ed. 2024, 63, e202319070.
2024-04-10
Total Synthesis of Mollanol A
Y. Wang, R. Zhao, M. Yang, J. Am. Chem. Soc. 2022, 144, 15033–15037.
Kovac lab 